(This is my opinion and will DEFINITLEY be different from person to person so please no toxicity i just wanna show my opinion and see what others think about the topic)
They're are a couple charaters downsides i personally think are almost non existent and i wish they could possibly be more impactful. Those characters being
-Willow: her downside of being slightly more affected by Winter is barely effectful since with a thermal stone and any source of fire (which is super accessible with Willow) its not dangerous at all.
-WX-78: Their downside of being damaged by water barely does anything since the damage is super low unless you're above 50 wetness and other than that it only removes his upside (which imo doesn't count as a downside if all it does is remove an upside).
-Woodie: His only downside is that you sometimes transform into his upside (and with perks it doesn't even do that).
-Winona: Her only downside is below 50 hunger you craft slower (which she crafts faster above it so ???)
-Wurt: this one many people will probaly disagree with and could have great points against it, but imo wurts downside of being a vegitarian is pretty much nonexistent once you go to lunar island and get stone fruit and kelp. Plus she gains extra hunger from them.
They're are a few more charaters but those ones could have many points against them (Wolf, Wanda, wicker etc.) but the ones above are the main ones imo. So if anyone agrees or disagrees pls respond with your opinions. Once again THIS IS MY OPINION AND WILL MOST DEFINITLEY BE DIFFERENT WITH OTHER PEOPLE. so please don't make this a Post filled with pointless arguments.
If anyone have any good ideas for more impactful downsides write your ideas below