2 resources that are rather hard to come by in the late game are fossils and bone shards. Fossils make for nice (mostly) indestructible barriers, but are a limited resource (unless cave rocks regenerate but I don't think they do), and bone shards, while renewable, are difficult to amass large quantities of, and ever since Eye of The Storm, bone shards are much more useful for providing infinite light thanks to mushlights. A simple fix to this issue would be to allow the bone armour and bone helmet dropped from the Ancient Fuelweaver to be deconstructed, giving 3-4 fossils and 4-5 bone shards. Bone helmets and armour are items that can build up very quickly in late game worlds, so it'd be nice to have a use, especially for all the bone armours which can only be destroyed by feeding them to a lureplant.
Another suggestion would be to allow the bee queen crown to be deconstructed for 6 or so honeycombs, as while you can get a lot of honeycombs (assuming you get a bee biome), they are pretty much only renewable by killing the bee queen, who only drops 1-2 per kill.
I'm sure these suggestions have been made before, but I'd like more attention to be drawn to the issue.